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1. Risperidone--Risperdal

1.1. Sedation

1.2. Involuntary restlessness

1.3. Hyperprolactinemia

1.4. Available in depot injections every 2 weeks

1.5. Acts like "typical" AP at higher doses

2. Olanzapine--Zyprexa

2.1. Known to cause the MOST weight gain

3. Quetiapine--Seroquel

3.1. Lowest risk of EPS

3.2. Low potency

3.3. Moderate sedation

3.4. Good choice for treating a depressive episode in Bipolar I

4. Clozapine--Clozaril

4.1. Agranulocytosis

4.2. Low potency

4.3. Weight gain

4.4. High sedation

4.5. NO tardive dyskinesia

4.6. QTc prolongation

4.7. Category B in pregnancy

5. Think "O" for Obesity

6. High and low potency a'psychotics — The high-potency: dosed in the range of 1 to 10s of milligrams and have low activity at histaminic and muscarinic receptors. They are associated with little sedation, weight gain, or anticholinergic activity, but a high risk for extrapyramidal side effects. The low-potency a'psychotics are dosed in 100s of milligrams and have high histaminic and muscarinic activity with a corresponding increased prevalence of sedation and anticholinergic effects, but lower risk of extrapyramidal side effects.

7. Aripiprazole--Abilify

7.1. Partial DA agonist

7.2. Minimal weight gain

8. Ziprasidone--Geodon

8.1. Known for QTc prolongation

8.2. Minimal weight gain

9. Think "Z" for ZERO weight gain

10. Lurasidone--Lutada

10.1. Category B in pregnancy

10.2. Good choice for treating a depressive episode in Bipolar I

11. Paliperidone--Invega

11.1. Available in MONTHLY depot injections

11.1.1. More convenient

11.2. Lower sedation compared to risperidone

12. Only effective treatment for pts who have failed tx with a conventional a'psychotic or an SGA